11/1/2022 0 Comments Vaginal obliterationTo our limited knowledge, vaginal obliteration as a complication of condition regimen has never been reported before. She initially received hormonal replacement therapy followed by surgical correction via vaginoplasty and two months of dilatory replacement and frequent coitus with satisfactory result. Physical examination showed a 2-cm short and blinded vaginal pouch. The patient visited our clinic due to difficulty in performing coitus. Fortunately, no recurrence of AML was noted. Nevertheless, she did not receive any hormonal replacement therapy and stopped her sexual life for two years. After TBI, the patient developed ovarian failure and amenorrhea, which was confirmed by hormonal evaluation. A 37-year-old married woman, G3P2, underwent high-dose cyclophosphamide accompanied by high dose (1575 cGy) total body irradiation (TBI) as part of her treatment for acute myeloid leukemia (AML: m1) when she was 35 years of age. We report a rare complication where a patient had complete vaginal obliteration after receiving a dose of total body irradiation (1575 cGy) as part of her treatment for acute myeloid leukemia. Although radiotherapy is an integral part in the management of certain types of hematological malignancies, its effect on the reproductive system has been well documented.
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